ACE inhibition is benificial in patients with coronary artery desease, but the mecanisms of action involved are unknown. it si possible thatb benefits effects observed during exercise in patients with coronary disorders are due to non-cardiac effects, such as periperal arterial of pulmonary function, rather than effect on cardiac function.
this study investigated the efficacy and tolerability of long-term treatment with perindopril(dai-ichi pharmaceutical) for the prevention of strees-induced myocardial ischemia in patients with coronary disorders.
In the present study, that the long-term treatment with perindopril prolonged the time to onset of symtomps and reduced the magnitude of electrocardiographic ST-segment changes and the left ventricullar wall motion score in the DSE(Dobutamin Stress Echocardiography) test. this is, to out knowledge, the first direct evidence t5hat long-term blocade patients with CAD(Coronary Artery Disease).
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