ACE inhibition is beneficial in patients with acute myocardial infarction (MI) but can cause hypotention which is associated morbidity and mortality. Perindopril has been shown to cause less hypotention in heart failure patients.
In patients with AMI (acute myocardial infarction), perindopril cause less hypotention than captopril on intiation of therapy. During the first 6 hours after the initial dose, the minimum levels of sistolic and diastolic BP were higher with perindopril, whereas the maximum decrease in BP observed was significantly earlier and greather with captopril. As a result the target dose of ACE inhibitor was attained in a higher proportion of patients on initiation...there was no difference in the clinical out come betwen the 2 treatments at 6 month
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