ACE Inhibitors such as perindopril improve outcomes in patients with ischemic heart disorders, althought the cellular mechanisms of action are not fully understood. this study investigated the effect of perindopril on expression of ACE, angiotensin type 1 reseptors, inducible nitric oxide synthase (NOS) and endothelial NOS in patients with ischemic heart disorders.
ACE inhibiton with perindopril for more than 2 weeks supressed both circulating and tissue ACE in the edothelium and adventitia of blood vessels and increased vascular eNOS (endothelial NOS) and iNOS (inducible NOS) expression in patient with ischemic heart desease. These effects of ACE inhibiton may play an important role in restoring endothelial dysfunction in patient with iscemic haert desease. However, ACE inhibition is also associated with increased vascular AT1 (angiotenton type 1) receptor expression, our results suggest that more animals studies and clinical trials are therefore required to addres further this important issue.
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