Previous mortality studies have indicated that the ideal target dosage of ACE inhibitors in patients with chronic heart failure is 50-100% of the maximum recomaded drug dosage.
The evidence available is consistent with the recommindation seen to recur in the medical literatur-that is, to titrate the dose of ACE inhibitor to the highest tolerated by each patient, aiming to at least meet the target doses of the major mortality studies. The problems is that the typical dose pescribed in current common practice falls weel short of this. critically, the findings of our study suggest that arround 25% of patients with chronic heart failure are receiving a suboptimal dose of ACE inhibitor without good reason. There also remains some room for improving the proportion of patients sterted on an ACE inhibitor.
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